The papulo-pustular reaction is the most common event during treatment with EGFR inhibitors.
The papulo-pustular reaction is the most common event during treatment with EGFR inhibitors. It occurs with the appearance of inflammatory papules or pustules at the level of hair follicles, especially in areas rich in sebaceous glands as the face and upper part of the trunk.
Fissures are long, narrow cracks that develop on the horny layer or deeper layers of the skin; they are caused by dryness, insufficient skin nutrition, the use of aggressive detergents and drugs, and so on.
Skin wounds may be caused accidentally because of a trauma, or deliberately as in the case of surgery. They may be only on the surface, such as scrapes or grazes, or deeper.
Dry dermatitis with cracking is considered an extreme case of dry skin in which the pathological dryness is associated with cracking of the horny layer.